Coagulation

From MedLabWiki

Factors II, V, VIII, HMWK -> cofactors

Factors II, VII, 9-12, Prekallikrein -> serine proteases

Vitamin K Dependent Factors

  • Serine Proteases
    • Factors II, VII, IX, X
    • Regulatory control proteins C, S, Z
Factor Other Names Pathway(s) Role Location of Synthesis
I Fibrinogen
II Prothrombin
III Tissue Factor (TF)
IV Ca2+
V Labile factor
VII Stable factor
VIII Anti-hemophilic factor
IX Christmas Factor
X Stuart-Prower Factor
XI PTA (Plasma Thromboplastin Antecedent)
XII Hageman Factor
XIII Fibrin Stabilizing Factor (FSF) Crosslinks adjacent fibrin strand D-domains to make an insoluble polymer
VWF
HMWK

Protein Z

  • Z-dependent protease inhibitor (ZPI)
  • Protein Z enhances ZPI activity
    • inhibits factor X and XI

Restoring Blood Flow

  • Fibrinolytic proteins
    • Plasminogen
      • Converted into plasmin by TPA and UPA
      • Plasmin helps restore blood flow
    • TPA
    • UPA

1.85*10^-3 x (100-HCT) x v

300ul citrate