Admin at 17:13, 7 March 2024

2024-03-07T17:13:44Z

@@ Line 72: / Line 72: @@
 * recurring infections and formation of granulomas from trapped bacteria
 ** rupture of granulomas can release bacteria and pus
 |}

Admin: Created page with "{| class="wikitable" |+ !Condition !Genetics !Affected Cells !Morphology & Testing !Effects |- |Pelger-Huet |Autosomal dominant |Neutrophils All WBCs may be affected |Heterozygous * Bi-lobed, mature neutrophils Homozygous * Round-to-oval nucleus without segmentation All lineages are affected! |Asymptomatic |- |Alder-Reilly |Autosomal recessive |Neutrophils, lymphs, and monos | * Neutrophilia with left shift * Dohle bodies * Toxic granulation in neuts * Large granules..."

2024-03-07T16:38:04Z

Created page with "{| class="wikitable" |+ !Condition !Genetics !Affected Cells !Morphology & Testing !Effects |- |Pelger-Huet |Autosomal dominant |Neutrophils All WBCs may be affected |Heterozygous * Bi-lobed, mature neutrophils Homozygous * Round-to-oval nucleus without segmentation All lineages are affected! |Asymptomatic |- |Alder-Reilly |Autosomal recessive |Neutrophils, lymphs, and monos | * Neutrophilia with left shift * Dohle bodies * Toxic granulation in neuts * Large granules..."

New page

{| class="wikitable"
|+
!Condition
!Genetics
!Affected Cells
!Morphology & Testing
!Effects
|-
|Pelger-Huet
|Autosomal dominant
|Neutrophils
All WBCs may be affected
|Heterozygous

* Bi-lobed, mature neutrophils

Homozygous

* Round-to-oval nucleus without segmentation

All lineages are affected!
|Asymptomatic
|-
|Alder-Reilly
|Autosomal recessive
|Neutrophils, lymphs, and monos
|
* Neutrophilia with left shift
* Dohle bodies
* Toxic granulation in neuts
* Large granules in lymphs and monos
|Asymptomatic
|-
|May-Heggalin
|Autosomal dominant
|Granulocytes and monocytes only
|
* Leukopenia with large basophilic inclusions in all granulocytes and monocytes
** Dohle-like bodies
* Variable thrombocytopenia
* Giant platelets
|Asymptomatic or mild bleeding disorders from thrombocytopenia
|-
|Chediak-Higashi
|Autosomal recessive
|All WBCs
|
* Giant granules in all WBC types
|Abnormal granule fusion causing large, mostly dysfunctional granules

* Ineffective phagocytosis and bacterial destruction
* Immunodeficiency
* Bleeding issues (due to platelets)
* Possible albinismUsually fatal
|-
|Chronic Granulomatous Disease
|X-linked or autosomal recessive
|Neutrophils
|Normal morphology or neutrophilia

* Possible toxic changes due to bacterial infections

Testing

* Nitroblue tetrazolium reduction test (unable to reduce substance from yellow -> blue)
* Flow cytometry (probes for NADPH oxidase)
* Genetic testing
* Presence of granulomas in tissue
|Inability to produce NADPH oxidase (reactive oxygen species)

* can ingest, but not kill bacteria
* recurring infections and formation of granulomas from trapped bacteria
** rupture of granulomas can release bacteria and pus
|}

Inherited Qualitative Abnormalities - Revision history

Admin at 17:13, 7 March 2024