Admin: Created page with "Hepatitis A virus * Fecal-oral transmission (foodborne and waterborne transmission) * Highest rates of infection in children (30% of all infections), asymptomatic in 90% of children under 5 years old * Acute onset of symptoms * Usually self-limiting disease with low mortality * Vaccination and immunoglobulin therapy available * Diagnosis by PCR or antibody detection (HAV IgM) Hepatitis B virus Hepatitis C * Has highest mortality rate of all hepatitis viruses * 50% de..."

2026-06-24T23:28:12Z

Created page with "Hepatitis A virus * Fecal-oral transmission (foodborne and waterborne transmission) * Highest rates of infection in children (30% of all infections), asymptomatic in 90% of children under 5 years old * Acute onset of symptoms * Usually self-limiting disease with low mortality * Vaccination and immunoglobulin therapy available * Diagnosis by PCR or antibody detection (HAV IgM) Hepatitis B virus Hepatitis C * Has highest mortality rate of all hepatitis viruses * 50% de..."

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Hepatitis A virus

* Fecal-oral transmission (foodborne and waterborne transmission)
* Highest rates of infection in children (30% of all infections), asymptomatic in 90% of children under 5 years old
* Acute onset of symptoms
* Usually self-limiting disease with low mortality
* Vaccination and immunoglobulin therapy available
* Diagnosis by PCR or antibody detection (HAV IgM)

Hepatitis B virus

Hepatitis C

* Has highest mortality rate of all hepatitis viruses
* 50% develop to chronic HCV, with 20-30% developing cirrhosis
* Diagnosis
** Recommended to use either point-of-care RNA testing, or a 2-step approach:
** Test for antibody detection (Anti-HCV)
*** Anti-HCV detected in 80% of patients within 6 weeks
*** Anti-HCV detected in 90% of patients within 12 weeks
** If Anti-HCV is positive, perform PCR test

{| class="wikitable"
|+
!
!
!
!
|-
|Anti-HCV
|Positive
|Positive
|Negative
|-
|PCR
|Positive
|Negative
|Positive
|-
|Interpretation
|Acute or chronic infection
|Past infection or
|Acute or chronic infection
|}

* Treatment with oral drugs effective in >95% of patients

Hepatitis D virus

* 1.7-kb ssRNA virus
* Requires HBV for replication (HBsAg required for virus envelope)
* Transmitted via blood or mucosal contact
* May occur as a result of co-infection of both viruses at the same time, or when someone with chronic HBV is exposed to HDV
* Often results in severe disease, including cirrhosis (66% progress to cirrhosis, with a 5% mortality rate)
* Diagnosis by PCR or antibody detection (HDV IgM and IgG)

Hepatitis E

Viral hepatitis - Revision history