ABO Rh Typing: Difference between revisions
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The ABO system is the most clinically significant blood group system in transfusion medicine. | |||
* Carbohydrate antigens | |||
* Non-RBC stimulated: individuals possess ABO antibodies to the antigens that they lack | |||
* IgM | |||
* Cause severe transfusion reactions | |||
** Cell lysis and hemolysis | |||
ABO Genes | |||
* A and B genes present on chromosome 9 | |||
* A and B co-dominant, O is recessive | |||
* One allele received from each parent | |||
ABO Typing | |||
* Babies: perform forward testing ONLY | * Babies: perform forward testing ONLY | ||
* Babies: if baby appears Rh Negative and the mother is Rh Negative, perform weak D testing | * Babies: if baby appears Rh Negative and the mother is Rh Negative, perform weak D testing | ||
Revision as of 14:08, 11 February 2025
The ABO system is the most clinically significant blood group system in transfusion medicine.
- Carbohydrate antigens
- Non-RBC stimulated: individuals possess ABO antibodies to the antigens that they lack
- IgM
- Cause severe transfusion reactions
- Cell lysis and hemolysis
ABO Genes
- A and B genes present on chromosome 9
- A and B co-dominant, O is recessive
- One allele received from each parent
ABO Typing
- Babies: perform forward testing ONLY
- Babies: if baby appears Rh Negative and the mother is Rh Negative, perform weak D testing
- AB Rh Positive patients require Rh Control to be performed
- RHC should be a reaction of 0. This checks that the agglutination seen is not a result of autoagglutination in the patient.
- Rh Control is also used for discrepancies (Rh testing results don't match, e.g. Anti-D1 is 2+ and Anti-D2 is 0)
- Rh Control is also used for IAT Testing (e.g., Weak D testing)