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Comparison of Leukocyte Conditions: Difference between revisions

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Created page with "{| class="wikitable" |+ !Condition !Characteristics !Causes ! |- |Normal adult | | | |- |Normal neonate | | | |- |Normal child (1-3 years) | | | |- |Normal geriatric adult | | | |- |Bacterial infection | | | |- |Leukemoid Reaction | | | |- |Leukoerythroblastic picture | | | |- |Basophilia | | | |- |Eosinophilia | | | |- | | | | |- |Pelger-Huët Anomaly | | | |- |Alder-Reilly Anomaly | | | |- |May-Hegglin Anomaly | | | |- |Chediak-Higashi Syndrome | | | |} Granulocyte Alt..."
 
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** May-Hegglin Anomaly
** May-Hegglin Anomaly
** Chediak-Higashi Syndrome
** Chediak-Higashi Syndrome
=== Reporting Leukocyte Morphology ===
{| class="wikitable"
|+
!
!
!
!
|-
|WBCs
|SD/D/N/SI/I
|
|
|-
|Platelets
|SD/D/N/SI/I
|
|
|-
| colspan="4" |'''Differential'''
|-
|Neutrophils
|
* All mature AND band neutrophils
|
|
|-
|Lymphocytes
|
* All mature lymphocytes, including reactive/atypicals
|
|
|-
|Monocytes
|
* All mature monocytes
|
|
|-
|Eosinophils
|
* All eosinophil lineage, including immature
|
|
|-
|Basophils
|
* All basophil lineage, including immature
|
|
|-
|Metamyelocytes
| rowspan="2" |
* Neutrophil lineage only
|
|
|-
|Myelocytes
|
|
|-
|Promyelocytes
| rowspan="2" |
* All cell lines
|
|
|-
|Blasts
|
|
|-
|Smudge Cells
|ONLY report if in large numbers AND consistent with CLL (Chronic Lymphocytic Leukemia)
|
|
|-
|Other Cells
|
* Hairy cells
* Plasma cells
|
|
|-
|Total
|
|
|
|-
|NRBC
|x per 100 WBCs
* Report if >0
* If ≥ 10, correct WBC count for NRBCs
|
|
|-
| colspan="4" |WBC Morphology
|-
|Bands
|Some/Many AND report Moderate/Marked left shift
|
|
|-
|Toxic granulation
|
|
|
|-
|Toxic vacuolation
|
|
|
|-
|Hypersegmented neutrophils
|
|
|
|-
|Hyposegmented neutrophils
|
|
|
|-
|Dohle bodies
|
|
|
|-
|Reactive lymphs
|
|
|
|-
| colspan="4" |Platelet Morphology
|-
|Giant Platelets
|
|
|
|-
|Platelet Clumps
|
|
|
|-
| colspan="4" |Comments
|-
|Other Comments
|See below.
|
|
|}
==== Report Under Comments: ====
* Moderate/Marked Left Shift (immature neutrophils)
* Immature WBCs
** Neutrophilic bands (>5% of neuts)
** Eosinophilic metamyelocytes
** Eosinophilic myelocytes
** Basophilic metamyelocytes
** Basophilic myelocytes
** Prolymphocytes
** Promonocytes
* Pelger-Huet forms
* Abnormal granulation
** Chediak-Higashi
** Alder-Reilly
* Auer rods
* Folded cells
* Bite/Blister cells
* Microspherocytes
* Intracellular/Extracellular Organisms
** Bacteria
** Malarial parasites
** Other parasites
* Hemoglobin Crystals
** Hemoglobin C
** Hemoglobin S/C
* Background staining
==== Possible Clinical Conditions: ====

Revision as of 17:55, 22 February 2024

Condition Characteristics Causes
Normal adult
Normal neonate
Normal child (1-3 years)
Normal geriatric adult
Bacterial infection
Leukemoid Reaction
Leukoerythroblastic picture
Basophilia
Eosinophilia
Pelger-Huët Anomaly
Alder-Reilly Anomaly
May-Hegglin Anomaly
Chediak-Higashi Syndrome

Granulocyte Alterations & Anomalies

  • Acquired
    • Hyposegmented nucleus
    • Hypersegmented nucleus
    • Pyknotic and necrobiotic nuclear forms
    • Toxic granulation of cytoplasm
    • Degranulation
    • Vacuolization
    • Döhle bodies
    • LE cells
    • Auer rods
    • Pseudo-Pelger-Huët Anomaly
  • Inherited
    • Pelger-Huët Anomaly
    • Alder-Reilly Anomaly
    • May-Hegglin Anomaly
    • Chediak-Higashi Syndrome

Reporting Leukocyte Morphology

WBCs SD/D/N/SI/I
Platelets SD/D/N/SI/I
Differential
Neutrophils
  • All mature AND band neutrophils
Lymphocytes
  • All mature lymphocytes, including reactive/atypicals
Monocytes
  • All mature monocytes
Eosinophils
  • All eosinophil lineage, including immature
Basophils
  • All basophil lineage, including immature
Metamyelocytes
  • Neutrophil lineage only
Myelocytes
Promyelocytes
  • All cell lines
Blasts
Smudge Cells ONLY report if in large numbers AND consistent with CLL (Chronic Lymphocytic Leukemia)
Other Cells
  • Hairy cells
  • Plasma cells
Total
NRBC x per 100 WBCs
  • Report if >0
  • If ≥ 10, correct WBC count for NRBCs
WBC Morphology
Bands Some/Many AND report Moderate/Marked left shift
Toxic granulation
Toxic vacuolation
Hypersegmented neutrophils
Hyposegmented neutrophils
Dohle bodies
Reactive lymphs
Platelet Morphology
Giant Platelets
Platelet Clumps
Comments
Other Comments See below.

Report Under Comments:

  • Moderate/Marked Left Shift (immature neutrophils)
  • Immature WBCs
    • Neutrophilic bands (>5% of neuts)
    • Eosinophilic metamyelocytes
    • Eosinophilic myelocytes
    • Basophilic metamyelocytes
    • Basophilic myelocytes
    • Prolymphocytes
    • Promonocytes
  • Pelger-Huet forms
  • Abnormal granulation
    • Chediak-Higashi
    • Alder-Reilly
  • Auer rods
  • Folded cells
  • Bite/Blister cells
  • Microspherocytes
  • Intracellular/Extracellular Organisms
    • Bacteria
    • Malarial parasites
    • Other parasites
  • Hemoglobin Crystals
    • Hemoglobin C
    • Hemoglobin S/C
  • Background staining

Possible Clinical Conditions:

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