Red Blood Cell Conditions: Difference between revisions

Revision as of 18:41, 18 February 2025

There are a variety of conditions that contribute to abnormal RBC function or counts.


Condition	Physiology	RBC	HGB	HCT	MCV	MCH	MCHC	RDW	Morphology
Blood loss/hemorrhage		N/↓	N	N	N	N	N	N	Normal
Iron Deficiency Anemia	Insufficient erythropoiesis	N/↓	N/↓	↓	↓	↓	↓	↑	Hypo/micro Ovals, pencils Tears, targets (occasional)
Anemia of Chronic Inflammation	Insufficient erythropoiesis								Normal or Hypo/micro
Sideroblastic Anemia	Ineffective erythropoiesis Deficient protoporphyrin synthesis	↓	↓	↓	N/↓	N/↓	N/↓	↑	Dual population Normochromic/normocytic Hypo/micro Pappenheimers



Lead poisoning		↓	↓	↓	N/↓	N/↓	N/↓	N	Normal OR hypo/micro Stomatocytes Coarse basophilic stippling
Thalassemia	Ineffective erythropoiesis								Hypo/micro
Megaloblastic Anemia	Ineffective erythropoiesis Vitamin B12 deficiency Folic acid deficiency Certain cancers or drugs				↑		N		Macrocytic/normochromic
Liver disease					↑		N		Macrocytic/normochromic
Aplastic Anemia	Insufficient erythropoiesis Hypocellularity due to autoimmune destruction				↑

Insufficient Erythropoiesis

Iron deficiency anemia
Erythropoietin deficiency (renal disease)
Loss of erythroid precursors
- Aplastic anemia (autoimmune)
- Infection
- Destruction/suppression of erythroid precursors (cancers, granulomas, fibrosis)

Anemias

Ineffective erythropoiesis
- Defective precursors made that are destroyed or function poorly
Insufficient erythropoiesis
Blood loss (acute or chronic)
Increased RBC destruction (hemolytic anemia)
- Shortened cell survival
- Intrinsic RBC defects
- Extrinsic RBC defects

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+There are a variety of conditions that contribute to abnormal RBC function or counts.
 {| class="wikitable"
 |+
 !Condition
+!Physiology
 !WBC
 !RBC
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 !Morphology
 !Followup Tests
+|-
+|Blood loss/hemorrhage
+|
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+|N/↓
+|N
+|N
+|N
+|N
+|N
+|N
+|
+|Normal
+|
 |-
 |Iron Deficiency Anemia
+|Insufficient erythropoiesis
 |
 |N/↓
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 * Ovals, pencils
 * Tears, targets (occasional)
+|
+|-
+|Anemia of Chronic Inflammation
+|Insufficient erythropoiesis
+|
+|
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+|
+|
+|
+|
+|
+|
+|Normal or Hypo/micro
 |
 |-
 |Sideroblastic Anemia
+|Ineffective erythropoiesis
+* Deficient protoporphyrin synthesis
 |
 |↓
@@ Line 46: / Line 80: @@
 Pappenheimers
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+|-
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+|-
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+|-
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 |
 |-
 |Lead poisoning
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 |
 |↓
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 |N
 |
-|Normo/normo OR hypo/micro
+|Normal OR hypo/micro
 * Stomatocytes
 * Coarse basophilic stippling
+|
+|-
+|Thalassemia
+|Ineffective erythropoiesis
+|
+|
+|
+|
+|
+|
+|
+|
+|
+|Hypo/micro
+|
+|-
+|Megaloblastic Anemia
+|Ineffective erythropoiesis
+* Vitamin B12 deficiency
+* Folic acid deficiency
+* Certain cancers or drugs
+|
+|
+|
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+|↑
+|
+|N
+|
+|
+|Macrocytic/normochromic
+|
+|-
+|Liver disease
+|
+|
+|
+|
+|
+|↑
+|
+|N
+|
+|
+|Macrocytic/normochromic
+|
+|-
+|Aplastic Anemia
+|Insufficient erythropoiesis
+* Hypocellularity due to autoimmune destruction
+|
+|
+|
+|
+|↑
+|
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+|
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+|
 |
 |}
+Insufficient Erythropoiesis
+* Iron deficiency anemia
+* Erythropoietin deficiency (renal disease)
+* Loss of erythroid precursors
+** Aplastic anemia (autoimmune)
+** Infection
+** Destruction/suppression of erythroid precursors (cancers, granulomas, fibrosis)
+Anemias
+* Ineffective erythropoiesis
+** Defective precursors made that are destroyed or function poorly
+* Insufficient erythropoiesis
+* Blood loss (acute or chronic)
+* Increased RBC destruction (hemolytic anemia)
+** Shortened cell survival
+** Intrinsic RBC defects
+** Extrinsic RBC defects