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Hemolysis, Icterus & Lipemia

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Revision as of 12:05, 30 January 2025 by Admin (talk | contribs) (Created page with "== Hemolysis == === Causes === * Intravascular ** Hemolytic anemia ** Transfusion reactions * Extravascular ** Vigorous mixing ** Venipuncture *** Difficult draw *** Tourniquet left on for too long *** Use of small needle (e.g., butterfly) - higher gauge is smaller needle (23 gauge is smaller than 21 gauge) ** Old sample === Interferences/Issues === * Release of cellular contents can falsely affect chemistry results * Damage to blood cells can affect hematology resul...")
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Hemolysis

Causes

  • Intravascular
    • Hemolytic anemia
    • Transfusion reactions
  • Extravascular
    • Vigorous mixing
    • Venipuncture
      • Difficult draw
      • Tourniquet left on for too long
      • Use of small needle (e.g., butterfly) - higher gauge is smaller needle (23 gauge is smaller than 21 gauge)
    • Old sample

Interferences/Issues

  • Release of cellular contents can falsely affect chemistry results
  • Damage to blood cells can affect hematology results
  • Can affect optical measurements

Icterus

  • Elevated bilirubin in blood due to disease states
  • May interfere with optical measurements at 400-540 nm
  • May interfere with certain test methods

Lipemia

  • High levels of fats/lipids in serum or plasma portion of blood
  • May be due to diet (recent fatty meal)
  • Can be pathological
  • Interferes with optical tests
    • Ultracentrifugation to remove lipids
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