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Comparison of Leukocyte Conditions

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Condition Characteristics Causes
Normal adult
Normal neonate
Normal child (1-3 years)
Normal geriatric adult
Bacterial infection
Leukemoid Reaction
Leukoerythroblastic picture
Basophilia
Eosinophilia
Pelger-Huët Anomaly
Alder-Reilly Anomaly
May-Hegglin Anomaly
Chediak-Higashi Syndrome

Granulocyte Alterations & Anomalies

  • Acquired
    • Hyposegmented nucleus
    • Hypersegmented nucleus
    • Pyknotic and necrobiotic nuclear forms
    • Toxic granulation of cytoplasm
    • Degranulation
    • Vacuolization
    • Döhle bodies
    • LE cells
    • Auer rods
    • Pseudo-Pelger-Huët Anomaly
  • Inherited
    • Pelger-Huët Anomaly
    • Alder-Reilly Anomaly
    • May-Hegglin Anomaly
    • Chediak-Higashi Syndrome

Reporting Leukocyte Morphology

WBCs SD/D/N/SI/I
Platelets SD/D/N/SI/I
Differential
Neutrophils
  • All mature AND band neutrophils
Lymphocytes
  • All mature lymphocytes, including reactive/atypicals
Monocytes
  • All mature monocytes
Eosinophils
  • All eosinophil lineage, including immature
Basophils
  • All basophil lineage, including immature
Metamyelocytes
  • Neutrophil lineage only
Myelocytes
Promyelocytes
  • All cell lines
Blasts
Smudge Cells ONLY report if in large numbers AND consistent with CLL (Chronic Lymphocytic Leukemia)
Other Cells
  • Hairy cells
  • Plasma cells
Total
NRBC x per 100 WBCs
  • Report if >0
  • If ≥ 10, correct WBC count for NRBCs
WBC Morphology
Bands Some/Many AND report Moderate/Marked left shift
Toxic granulation
Toxic vacuolation
Hypersegmented neutrophils
Hyposegmented neutrophils
Dohle bodies
Reactive lymphs
Platelet Morphology
Giant Platelets
Platelet Clumps
Comments
Other Comments See below.

Report Under Comments:

  • Moderate/Marked Left Shift (immature neutrophils)
  • Immature WBCs
    • Neutrophilic bands (>5% of neuts)
    • Eosinophilic metamyelocytes
    • Eosinophilic myelocytes
    • Basophilic metamyelocytes
    • Basophilic myelocytes
    • Prolymphocytes
    • Promonocytes
  • Pelger-Huet forms
  • Abnormal granulation
    • Chediak-Higashi
    • Alder-Reilly
  • Auer rods
  • Folded cells
  • Bite/Blister cells
  • Microspherocytes
  • Intracellular/Extracellular Organisms
    • Bacteria
    • Malarial parasites
    • Other parasites
  • Hemoglobin Crystals
    • Hemoglobin C
    • Hemoglobin S/C
  • Background staining

Possible Clinical Conditions: