Blood Products

Product	Collection	Additives	Properties	Storage Life/Expiry
Frozen Plasma	Separated from whole blood (frozen within 24h)	CPD	Slightly reduced Factors V and VIII	Frozen: -18°C for 12 months Thawed: 1-6°C for 5 days
Apheresis Fresh Frozen Plasma	Apheresis (frozen within 8h)	Sodium citrate	Contains liable factors (V & VIII) and non-liable factors	1-6° for 24h
Apheresis Frozen Plasma	Apheresis (frozen within 24h)	ACD-A		Frozen: -18°C for 12 months Thawed: 1-6°C for 5 days
Cryosupernatant Plasma	From Frozen Plasma (slow thawed) Insoluble cryoprecipitate separated from cryosupernatant via centrifugation Each is separated into its own product		Has reduced VWF and reduced high molecular weight multimers Can be used for plasma exchange in TTP and HUS patients Can be used for patients on Warfarin, where Vitamin K cannot reverse effects quickly enough, and prothrombin complex concentrate (Octaplex) is unavailable	Frozen: -18°C for 12 months Thawed: 1-6°C for 5 days
Cryoprecipitate			Contains fibrinogen, Factors VIII, XIII, VWF, and fibronectin Can be used for patients requiring fibrinogen or FXIII supplementation Can be used for bleeding in VWD and Factor VIII deficient patients when desmopressin (DDAVP) is ineffective and factor concentrates are unavailable	Frozen: -18°C for 12 months Thawed: 20-24°C for 4h
Octaplasma® Solvent-Detergent (SD) Plasma	Pooled plasma manufactured by Octapharma		Used interchangeably with Frozen Plasma (replacing stock within Canada) Removal of enveloped viruses, bacteria, protozoa, and prions Removal of WBCs decreases risk of GVHD Reduced risk of TRALI
RBCs for Intrauterine Transfusion	Fresh RBCs (<7 days old) O Rh Negative Irradiated (prevent GVHD) Hemoglobin S negative CMV negative			Use within 7 days

Blood-Derived Pharmaceuticals/Other Blood-Related Products

Product	Collection	Additives	Properties	Storage Life/Expiry
Octaplex®			Human Prothrombin Complex (HPC) Contains Prothrombin (Factor II), Factors VII, IX, X, Protein C and Protein S Uses Treatment of deficiencies in prothrombin complex coagulation factors Reversal of warfarin or other Vitamin K antagonists when Vitamin K does not work or reversal is needed quickly Preferred over cryosupernatant plasma for this purpose