Coagulation

Factors II, V, VIII, HMWK -> cofactors

Factors II, VII, 9-12, Prekallikrein -> serine proteases

Vitamin K Dependent Factors

• Serine Proteases
  • Factors II, VII, IX, X
  • Regulatory control proteins C, S, Z

Factor	Other Names	Pathway(s)	Role	Location of Synthesis
I	Fibrinogen	Common
II	Prothrombin	Common
III	Tissue Factor (TF)
IV	Ca2+
V	Labile factor	Common
VII	Stable factor	Extrinsic
VIII	Anti-hemophilic factor	Intrinsic
IX	Christmas Factor	Intrinsic
X	Stuart-Prower Factor	Common
XI	PTA (Plasma Thromboplastin Antecedent)	Intrinsic
XII	Hageman Factor	Intrinsic
XIII	Fibrin Stabilizing Factor (FSF)		Crosslinks adjacent fibrin strand D-domains to make an insoluble polymer
VWF
HMWK	High Molecular Weight

Stages of Hemostasis

1. Primary hemostasis
2. Secondary hemostasis
3. Fibrin clot formation
4. Coagulation inhibition

Protein Z

• Z-dependent protease inhibitor (ZPI)
• Protein Z enhances ZPI activity
  • inhibits factor X and XI

Restoring Blood Flow

• Fibrinolytic proteins
  • Plasminogen
    • Converted into plasmin by TPA and UPA
    • Plasmin helps restore blood flow
  • TPA
  • UPA

1.85*10^-3 x (100-HCT) x v

300ul citrate